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Cell Biology and Neuroscience

Professors
Michael E. Adams, Ph.D. (Cell Biology and Neuroscience/Entomology)
John H. Ashe, Ph.D. (Cell Biology and Neuroscience/Psychology)
Nancy E. Beckage, Ph.D. (Cell Biology and Neuroscience/Entomology)
David A. Eastmond, Ph.D.
Sarjeet S. Gill, Ph.D.
Andrew J. Grosovsky, Ph.D.
Glenn I. Hatton, Ph.D.
B. Glenn Stanley, Ph.D. (Cell Biology and Neuroscience/Psychology)
Prudence Talbot, Ph.D.
Raphael Zidovetzki, Ph.D.
Professors Emeriti
Katharine D. Atkinson, Ph.D.
Paul D. Wilson, Ph.D. (Cell Biology and Neuroscience/Psychology)
Associate Professors
Margarita C. Currás-Collazo, Ph.D.
Scott N. Currie, Ph.D.
Manuela Martins-Green, Ph.D.
Frances M. Sladek, Ph.D.
Assistant Professors
Jeffrey B. Bachant, Ph.D.
Gene S. Huh, Ph.D.
Constance I. Nugent, Ph.D.
Vladimir Parpura, M.D., Ph.D.

Research in the Department of Cell Biology and Neuroscience uses multidisciplinary approaches to understanding basic cellular processes in various tissues, including the nervous system, as well as more integrative levels of analysis, including behavior. Areas of research represented in the department include the following:

• Biophysical properties of excitable membranes
• DNA repair
• Transcriptional regulation
• Mechanisms of toxicity
• Insect development
• Membrane transport
• Mechanisms of mitotic chromosome transmission
• Telomere maintenance
• Synaptic structure and function
• Changes in nervous system with experience
• Interactions of nervous and endocrine systems
• Reproductive biology and fertilization
• Chemokine function in wound healing and tumor development
• Glia-neuron signaling and sensory and motor integrative processes

UNDERGRADUATE CURRICULUM

Students interested in cell, molecular, and developmental biology can obtain training through the interdepartmental major in Biological Sciences with a specialization in Cell, Molecular, and Developmental Biology leading to the B.S. degree. Students interested in neuroscience can obtain training in behavioral neuroscience, neurobiology, and neurochemistry through the Neuroscience major leading to the B.A. or B.S. degree. The Neuroscience major is an intercollege major offered by the College of Humanities, Arts, and Social Sciences and the College of Natural and Agricultural Sciences. See Biological Sciences section and Neuroscience Undergraduate Major section, respectively.

GRADUATE CURRICULUM

Courses and research opportunities are offered by the interdepartmental graduate programs in Cell, Molecular, and Developmental Biology; Environmental Toxicology; and Neuroscience. See the respective graduate program section.

UPPER-DIVISION COURSES

CBNS 101. Fundamentals of Cell Biology (4) Lecture, 3 hours; discussion, 1 hour. Prerequisite(s): BIOL 005A, BIOL 005B, BIOL 005C, CHEM 001C or CHEM 01HC, CHEM 112C, MATH 009B or MATH 09HB, PHYS 002C, PHYS 02LC, BCH 100 or BCH 110A (BCH 100 or BCH 110A may be taken concurrently). Introduces the principles of eukaryotic cell biology. Includes an examination of the molecules and systems that mediate cell function and an overview of membrane architecture and function, cell signaling and signal transduction, the cytoskeleton, organelles, protein targeting and secretion, and the nucleus and nuclear transport. Credit is not awarded for CBNS 101 if it has already been awarded for BIOL 113 or BIOL 114.

CBNS 106. Introduction to Neuroscience (4) Lecture, 3 hours; discussion, 1 hour. Prerequisite(s): BIOL 005A, BIOL 005B, CHEM 001A, CHEM 001B, CHEM 001C; or consent of instructor. An introduction to cellular, organismal, and behavioral neuroscience for science majors. Topics include structure and functions of the brain, neurons, and synapses; sensory systems and perception; control of movement; neurobiology of hormones and sexual behavior; biorhythms, learning, memory, and psychoses.

CBNS 108. Introduction to Developmental Biology (4) Lecture, 3 hours; discussion, 1 hour. Prerequisite(s): BIOL 005A, BIOL 05LA, BIOL 005B, BIOL 005C, BIOL 102, CHEM 001C or CHEM 01HC, CHEM 112C, MATH 009B or MATH 09HB, PHYS 002C, PHYS 02LC, BCH 100 (BCH 100 may be taken concurrently), one course in statistics; or consent of instructor. Emphasizes common principles and key concepts that govern development of multiple eukaryotic systems, and how genes control cell behavior during development.

CBNS 116. Cellular Neuroscience: Structure-Function Relationships (4) Lecture, 3 hours; discussion, 1 hour. Prerequisite(s): CBNS 106 or consent of instructor. Examination of structures comprising nervous systems and the functional principles around which these structures are organized. Topics range from whole brain anatomy to the cellular units (neurons and glia) that constitute nervous systems, and to subcellular elements important in neural functioning.

CBNS 120. Cellular Neuroscience: Membrane and Synaptic Phenomena (4) Lecture, 3 hours; discussion, 1 hour. Prerequisite(s): CBNS 106 or consent of instructor. An examination of cellular and molecular mechanisms of nervous system function using concepts drawn from the study of vertebrates and invertebrates with emphasis on mammalian systems. Cross-listed with PSYC 120.

CBNS 120L. Neuroscience Laboratory (2) Lecture, 1 hour; laboratory, 3 hours. Prerequisite(s): CBNS 120/
PSYC 120 or concurrent enrollment. Laboratory experiments using electrophysiological, chemical, and anatomical research methods fundamental to understanding neurons and neural systems. Cross-listed with PSYC 120L.

CBNS 121. Developmental Neuroscience (4) Lecture, 3 hours; discussion, 1 hour. Prerequisite(s): CBNS 106 or consent of instructor. A study of the development of nervous systems. Examines the cellular and molecular mechanisms of neural development and the determinants of cell birth and death, axonal pathfinding, neuronal connections, and development of neural systems underlying behavior.

CBNS 124. Systems Neuroscience (4) Lecture, 3 hours; discussion, 1 hour. Prerequisite(s): CBNS 106 or consent of instructor. Study of the structure and function of motor, sensory, and motivational systems in vertebrate and invertebrate nervous systems. Cross-listed with PSYC 124.

CBNS 125. Neuropharmacology (4) Lecture, 3 hours; discussion, 1 hour. Prerequisite(s): CBNS 120/
PSYC 120; previous or concurrent enrollment in CBNS 120L/PSYC 120L and CBNS 124/PSYC 124 recommended. Examines synaptic neurotransmitter systems, mechanisms, and pharmacological agents and effects, which are fundamental to neural information processing. Cross-listed with PSYC 125.

CBNS 126. Neurobiology of Learning and Memory (4) Lecture, 3 hours; discussion, 1 hour. Prerequisite(s): CBNS 120/PSYC 120 or consent of instructor. Covers recent research and advances in the understanding of the physiological, anatomical, and biochemical basis of information acquisition and retention in nonhuman and human brain. Cross-listed with PSYC 126.

CBNS 127. Behavioral Control Systems (4) Lecture, 3 hours; discussion, 1 hour. Prerequisite(s): CBNS 120/PSYC 120; CBNS 124/PSYC 124 strongly recommended. An analysis of the principles of nervous system operation from the processing of sensory inputs for object recognition and localization to the organization of central patterns for generation of sequenced motor output. Cross-listed with PSYC 127.

CBNS 128. Immunology (3) Lecture, 3 hours. Prerequisite(s): BIOL 005A, BIOL 05LA, BIOL 005B, BIOL 005C, CBNS 101 or BIOL 113 or BIOL 114, CHEM 001C or CHEM 01HC, CHEM 112C, MATH 009B or MATH 09HB, PHYS 002C, PHYS 02LC, BCH 100 or BCH 110A, one course in statistics. A study of humoral and cellular immunology. Topics include lymphoid systems, cells, antigens, antibodies, antibody formation, cellular immunity, and tumor and transplantation immunology. Diseases and altered immune states associated with each topic are discussed in detail. Cross-listed with BIOL 128.

CBNS 150. Cancer Biology (4) Lecture, 3 hours; discussion, 1 hour. Prerequisite(s): BCH 110C or BIOL 107A; CBNS 101 is recommended (may be taken concurrently). The origin, development, and treatment of cancer are explored with emphasis on molecular mechanisms. Topics such as oncogenes, tumor suppressors, cell cycle an differentiation, AIDS, and hereditary and environmental factors in the development of cancer are covered. Cross-listed with ENTX 150.

CBNS 169. Human Embryology (4) Lecture, 3 hours; laboratory, 3 hours. Prerequisite(s): BIOL 005A, BIOL 005B, BIOL 005C, CHEM 001C or CHEM 01HC, CHEM 112C, MATH 009B or MATH 09HB, PHYS 002C, PHYS 02LC, BCH 110A, STAT 105, third-year standing in the Biomedical Sciences Program; or consent of instructor. An in-depth study of normal human development from conception through the early postnatal period. Demonstrations use microscopic and other materials specifically adapted for the course. Some consideration is given to abnormal development.

CBNS 191. Seminar in Neuroscience (3) Seminar, 3 hours. Prerequisite(s): CBNS 120/PSYC 120 and one other upper-division Neuroscience course, or consent of instructor; upper-division standing. Lectures by the instructor and oral presentations by students on selected topics with emphasis on current research in neuroscience. Instructor and the topic vary. Written assignment. Course is repeatable to a maximum of 6 units.

CBNS 194. Independent Reading (1-2) Individual study, 3-6 hours. Prerequisite(s): consent of instructor. Individual reading under faculty direction. Course is repeatable to a maximum of 4 units.

CBNS 197. Research for Undergraduates (1-4) Outside research, 3-12 hours. Prerequisite(s): CBNS 120/
PSYC 120 (or concurrent enrollment); consent of instructor. An introduction to laboratory research under the supervision of a faculty member. Course is repeatable.

CBNS 199. Senior Research (1-4) Outside research, 3-12 hours. Prerequisite(s): open to seniors by invitation of faculty; CBNS 120/PSYC 120. Original research undertaken under the direction of a faculty member. Course is repeatable.