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2006-2007 General Catalog
University of California, Riverside Bioengineering Subject abbreviation: BIEN
Jerome S. Schultz, Ph.D., Chair Professors Assistant Professors The major in Bioengineering allows students to complete a B.S. degree that provides a basic education to enter the fields of bioengineering and biotechnology. Bioengineering is rooted in physics, mathematics, chemistry, biology, and the life sciences. It is the application of a systematic, quantitative, and integrative way of thinking about and approaching the solutions of problems important to biology, health, and clinical practice. Bioengineers develop processes and products that are important for health and treatment of diseases, new materials, protecting environments, and food production. They are employed by the pharmaceutical, biotechnology, medical device, and environmental and food industries. For students interested in medicine, the bioengineering program provides the basic courses to prepare for application to medical schools. The objective of the bioengineering program is to produce graduates who: • have life-long learning skills that maintain their high level of professional competence • have the skills to apply engineering and biological principles to meet the challenges of this rapidly evolving field • be prepared for advanced postgraduate training in bioengineering and biomedical allied fields The Intersegmental General Education Transfer Curriculum (IGETC) does not meet transfer requirements for Engineering. All undergraduates in the College of Engineering must see an advisor at least annually. Visit www.engr.ucr.edu/studentaffairs for details. University Requirements See Undergraduate Studies section. College Requirements See The Marlan and Rosemary Bourns College of Engineering, Colleges and Programs section. The Bioengineering major uses the following major requirements to satisfy the college’s Natural Sciences and Mathematics breadth requirement. 1. BIOL 005A, BIOL 05LA 2. CHEM 001A, CHEM 001B, CHEM 001C 3. MATH 008B or MATH 009A 1. Lower-division requirements (75 units) a) BIOL 005A, BIOL 05LA, BIOL 005B, BIOL 005C b) CHEM 001A, CHEM 001B, CHEM 001C, CHEM 01LA, CHEM 01LB, CHEM 01LC c) CEE 011 d) MATH 008B or MATH 009A, MATH 009B, MATH 009C, MATH 010A, MATH 010B, MATH 046 e) ME 001C, ME 010, ME 018 f) PHYS 040A, PHYS 040B, PHYS 040C 2. Upper-division requirements (86 units) a) BCH 100, BCH 102 b) BIEN 110, BIEN 120, BIEN 125, BIEN 130, BIEN 130L, BIEN 135, BIEN 140A/CEE 140A, BIEN 140B/CEE 140B, BIEN 155, BIEN 175A, BIEN 175B c) CHEM 112A, CHEM 112B, CHEM 112C d) ME 118, ME 138 e) STAT 105 f) Technical electives (16 units): upper-division courses in engineering, biology and/or substantive courses in a field(s) related to bioengineering Visit the Student Affairs Office in the College of Engineering or www.engr.ucr.edu/studentaffairs for a sample program. The College of Engineering has proposed an Interdepartmental Graduate Program to offer M.S. and Ph.D. degrees in Bioengineering that is in its final stages of approval. Students seeking admission into the program should meet all general requirements of the Graduate Division as printed in the Graduate Studies section of this catalog. Students must have completed course work in chemistry, physics, mathematics, biochemistry, biology, and engineering. Students without an undergraduate engineering degree should have excellent training in mathematics and the physical sciences. Students with strong academic records may be admitted with limited course work deficiencies, provided that these are satisfied by appropriate course work taken during the first two years of graduate study. Entry into the program requires an undergraduate or graduate degree in an engineering, physical, or biological science subject and acceptable performance on the GRE (General Test). Further information on the graduate program can be found on the Web page for the Bioengineering Department: www.bioeng.ucr.edu. BIEN 110. Biomechanics of the Human Body (4) Lecture, 3 hours; discussion, 1 hour. Prerequisite(s): CHEM 001C or CHEM 01HC, MATH 010A, ME 010, PHYS 040B. Introduces the motion, structure and function of the musculoskeletal system, the cardiovascular system, and the pulmonary system. Topics include applied statics, kinematics, and dynamics of these systems and the mechanics of various tissues (ligament, bone, heart, blood vessels, lung). Emphasis is on the relation between function and material properties of these tissues. BIEN 120. Biosystems and Signal Analysis (4) Lecture, 3 hours; discussion, 1 hour. Prerequisite(s): BIOL 005B, CS 010, MATH 046, PHYS 040C. Provides basic knowledge for the quantitative analysis of the dynamic behavior of biological systems. Particular applications include neural systems, control of metabolic and hormonal systems, and design of instruments for monitoring and controlling biological systems. Topics include system theory, signal properties, control theory, and transfer functions. BIEN 125. Biotechnology and Molecular Bioengineering (4) Lecture, 3 hours; discussion, 1 hour. Prerequisite(s): BCH 100 or BCH 110A. Provides an overview of biochemical processes in cells and their use in developing new products and processes. Presents cellular processes such as metabolism, protein synthesis, enzyme behavior, and cell signaling and control from an engineering viewpoint of modeling and control. BIEN 130. Bioinstrumentation (4) Lecture, 3 hours; discussion, 1 hour. Prerequisite(s): BIEN 120. Introduces basic components of instruments for biological applications. Explores sources of signals and physical principles governing the design and operation of instrumentation systems used in medicine and physiological research. Topics include data acquisition and characterization; signal-to-noise concepts and safety analysis; and interaction of instrument and environment. BIEN 130L. Bioinstrumentation Laboratory (2) Laboratory, 3 hours; discussion, 1 hour. Prerequisite(s): BIEN 130. Laboratory experience with instrumental methods of measuring biological systems. Introduces various sensors and transducers to measure physical, chemical, and biological properties. Covers reliability, dynamic behavior, and data analysis. BIEN 135. Biophysics and Biothermodynamics (4) Lecture, 3 hours; discussion, 1 hour. Prerequisite(s): BIEN 125, MATH 046, PHYS 040B. An introduction to the application of thermodynamic principles to understanding the behavior of biological systems. Discusses biophysical properties of biomacromolecules, such as proteins, polynucleotides, carbohydrates, and lipids, and methods of characterizing their properties and interactions. BIEN 140A. Biomaterials (4) Lecture, 3 hours; discussion, 1 hour. Prerequisite(s): BCH 100 or BCH 110A; CHEM 112C; MATH 010B; PHYS 040B. Covers the principles of materials science and engineering, with attention to topics in bioengineering. Discusses atomic structures, hard treatment, fundamentals of corrosion, manufacturing processes, and characterization of materials. Cross-listed with CEE 140A. BIEN 140B. Biomaterials (4) Lecture, 3 hours; discussion, 1 hour. Prerequisite(s): BIEN 140A/CEE 140A. Covers the structure-property relations of metals, ceramics, polymers, and composites, as well as hard and soft tissues such as bone, teeth, cartilage, ligament, skin, muscle, and vasculature. Focuses on behavior of materials in the physiological environment. Cross-listed with CEE 140B. BIEN 155. Bioengineering Laboratory (2) Laboratory, 3 hours; discussion, 1 hour. Prerequisite(s): BCH 102. Laboratory experience in cell culture, bioreactors, optical techniques, array techniques, and separation and purification methods. BIEN 175A. Senior Design (4) Lecture, 2 hours; practicum, 3 hours; discussion, 1 hour. Prerequisite(s): BIEN 130; senior standing in Bioengineering. Preparation of formal engineering reports and statistical analysis on a series of problems illustrating methodology from various branches of applied bioengineering. Covers the entire design process: design problem definition, generation of a design specification, documentation, design review process, prototype fabrication, testing and calibration, cost estimation, and federal guidelines. Requires a term project and oral presentation. Graded In Progress (IP) until BIEN 175A and BIEN 175B are completed, at which time a final, letter grade is assigned. BIEN 175B. Senior Design (4) Lecture, 1 hour; practicum, 6 hours; discussion, 1 hour. Prerequisite(s): BIEN 175A; senior standing in Bioengineering. Preparation of formal engineering reports and statistical analysis on a series of problems illustrating methodology from various branches of applied bioengineering. Covers the entire design process: design problem definition, generation of a design specification, documentation, design review process, prototype fabrication, testing and calibration, cost estimation, and federal guidelines. Requires a term project and oral presentation. Satisfactory (S) or No Credit (NC) grading is not available. BIEN 220. Chemical Genomics Design Studio (2) Lecture, 1 hour; practicum, 4 hours. Prerequisite(s): Course work in cell biology, genetics, combinatorial chemistry; or consent of instructor; graduate standing. Explores chemical genomic research approaches. Emphasizes critical thinking; advanced planning of time-consuming tests of hypotheses and experimental caveats, trade-offs, and options. Taught in a case-study approach, teams consist of students with engineering, biology, computational sciences, and chemical backgrounds. Teams generate an interdisciplinary chemical genomic research project. May be taken Satisfactory (S) or No Credit (NC) with consent of instructor and graduate advisor. Cross-listed with CMDB 220. BIEN 245. Fluoresence Methods in Biology and Chemistry (3) Lecture, 3 hours. Prerequisite(s): CHEM 109 or equivalent, graduate standing, consent of instructor. Topics include the origin of fluorescence and other emission processes that modulate the characteristics of molecular emissions. Presents emission-based analytical and bioanalytical methods and techniques. Reviews state-of-the-art instrumentation, including their applicability, limitations, and source, as well as interpretation and meaning of the measured signals, with applications to biological systems. May be taken Satisfactory (S) or No Credit (NC) with consent of instructor and graduate advisor. Course is repeatable as content changes. BIEN 249. Integration of Computational and Experimental Biology (4) Lecture, 3 hours; laboratory, 3 hours. Prerequisite(s): BIOL 005B; MATH 009B or MATH 09HB; graduate standing. Multidisciplinary introduction to the mathematical concepts of design of experiments, information content, causation versus correlation, and statistical analysis with respect to hypothesis testing, model development, and parameter estimation. Covers state-of-the-art experimental techniques in proteomics, transcriptomics, metabolomics, and genetics. May be taken Satisfactory (S) or No Credit (NC) with consent of instructor and graduate advisor. Cross-listed with CEE 249. BIEN 261. Special Topics in Biotransport (1 or 2) Seminar, 1 hour; term paper, 0-3 hours. Prerequisite(s): graduate standing or consent of instructor. Focuses on advanced methods of analysis of biological transport phenomena such as drug distribution, microcirculation, membrane transport, and transport in organs and tissues. Students who submit a term paper receive credit for 2 units; other students receive credit for 1 unit. Students who submit a term paper receive a letter grade; other students receive a Satisfactory (S) or No Credit (NC) grade. Course is repeatable. BIEN 262. Special Topics in Biosignaling (1 or 2) Seminar, 1 hour; term paper, 0-3 hours. Prerequisite(s): graduate standing or consent of instructor. Focuses on current research in cell signaling and control, including G protein-coupled receptors, signal transduction and cytoskeletal dynamics, and cell adhesion and cell metabolism. Students who submit a term paper receive credit for 2 units; other students receive credit for 1 unit. Students who submit a term paper receive a letter grade; other students receive a Satisfactory (S) or No Credit (NC) grade. Course is repeatable.
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